Trazodone What Is It & Why Weed is Better

What is Trazodone

Trazodone, somtimes called Trazodone hydrochloride or Trazodone HCL, is an antidepressant. It’s among a class of medications called serotonin modulators which work by moderating levels of serotonin in the brain. The Food and Drug Administration (FDA) first approved trazodone under the brand name Desyrel in 1981. Trazodone is also available as a generic drug produced by multiple drug companies. The only brand name remaining for trazodone is called Oleptro.

Trazodone comes in a tiny pill that you swallow of course. However snorting trazodone is a thing apparently. We’ll get to that later, man. Anyhow Trazadone affects the chemicals in the brain that may be unbalanced in people with depression. It’s often used to treat major depressive disorder. Marijuana is also an antidepressant and can be used to treat depression as well as myriad other ailments. Now we’re stoners not doctors, so you should always check with your physician about the drugs you are taking, but that shouldn’t stop you from knowing that weed might be a great alternative to Trazodone to treat depression or insomnia. You can eat it, smoke it or pop it in your vape pen and not have to suffer the terrible side-effects that come with pharmaceutical drugs. We encourage you to educate yourself on Trazadone and marijuana and make an informed decision.

What is trazodone used for

Like we mentioned above, Trazodone is an antidepressant commonly used to treat anxiety disorder and unipolar depression. According to wikipedia many clinicians use low-dose trazadone as an alternative to benzodiazepines for the treatment of insomnia. Two recent reviews found that trazodone is the second most prescribed agent for insomnia, but as most studies have been limited to patients with depression, few studies actually support trazodone’s use in primary insomnia. As a matter of fact treating insomnia with trazodone is considered an off-label use in some countries. Other off-label uses of Trazodone include treating things like



  • Fibromyalgia
  • Complex regional pain syndrome
  • Panic disorder
  • Diabetic neuropathy
  • Bulimia nervosa
  • Obsessive-compulsive disorder (OCD)
  • Alcohol withdrawal
  • Schizophrenia as an adjunct to improve negative symptoms
  • Erectile dysfunction

Trazodone dosage

There are two different tablets of Trazodone Immediate-release and Extended-release tablets. Here’s what drugs.com says about taking them:

Trazodone Immediate-release tablets:
Initial dose: 150 mg per day in divided doses.
Maintenance dose: May be increased by 50 mg per day every 3 to 4 days. The maximum dose for outpatients usually should not exceed 400 mg per day in divided doses. Inpatients may be given up to but not in excess of 600 mg per day in divided doses. Trazodone should be taken shortly after a meal or light snack.

Trazodone Extended-release tablets:
Recommended starting dose: 150 mg once daily
Maintenance dose: The dose may be increased by 75 mg/day every three days (for example, start 225 mg on day 4 of therapy).
Maximum daily dose: 375 mg
Trazodone extended-release tablets should be taken orally at the same time every day, in the late evening preferably at bedtime, on an empty stomach. Once an adequate response has been achieved, dosage may be gradually reduced, with subsequent adjustment depending on therapeutic response.

Trazodone aka Trazodone HCL is an antidepressant among a class of medications called serotonin modulators

Side Effects of Trazodone

Like marijuana Trazadone has antianxiety and sleep-inducing effects, however unlike marijuana it has a the potential for toxicity and several negative side-effects these include:

  • Headache
  • Muscle ache
  • Nausea, vomiting, loss of appetite, or stomachache
  • Constipation or diarrhea
  • Loss of interest in sex (erectile dysfunction in men)
  • Dizziness or loss of balance
  • Dry mouth or dry eyes
  • Numbness, burning, or tingling sensations
  • Confusion
  • Blurred vision
  • Ringing in the ears
  • Nervousness or confusion
  • Rash
  • Sweating
  • Weakness or fatigue

Serious side effects can occur too:

  • Worsening depression
  • Suicidal thoughts
  • A severe rash or hives
  • Swelling of the face, lips, or tongue
  • Chest pain
  • Difficulty breathing
  • A painful erection that will not go away (priapism)
  • Panic attack
  • Irregular heartbeat
  • Fainting
  • Unusual bruising or bleeding
  • Seizure

We’ve also heard of tunnel vision, eye pain or swelling, or seeing halos around lights occuring when taking Trazodone as well as agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;

According to drugs.com you should stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 6 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery.

Taking Trazodone hcl could increase the chance of becoming suicidal

Trazodone and alcohol

If you are taking Trazodone do not drink alcohol. Trazodone can increase the effects of alcohol, which could be dangerous. Plus an overdose of trazodone can be fatal when it is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium).

Overdose symptoms may include extreme drowsiness, vomiting, penis erection that is painful or prolonged, fast or pounding heartbeat, seizure (black-out or convulsions), or breathing that slows or stops.

Trazodone withdrawal

Trazodone patients should be monitored for withdrawal symptoms when discontinuing treatment with trazodone hydrochloride, aka Trazodone HCL. The dose should be gradually reduced whenever possible.

Trazodone high

Apparently you can get high as fuck by snorting trazodone hcl. We ran into a post on erowid.com, a non-profit educational organization that provides information about psychoactive plants and chemicals, left by a guy who gave snorting Trazodone a try. This is what he said:

After about 45 minutes from taking the first line I noticed that colors became more defined and things began to move in a sort of slow motion. Objects became outlined and everything seemed to stand out. I got up to get a drink of water and my balance was about the same as it would be after getting drunk; I had a very hard time walking straight. At about this time my mood jumped; I became extremely happy and couldn’t stop smiling.

An hour after the first line was taken I began to get a pleasant body sensation that is somewhat comparable to a low dose of heroine and my body just pulsed with good feeling. I went to the bathroom to see how I looked and I saw that my eyes were red and my veins were bulging. At that point I checked my pulse and found that my heart was beating a little faster than usual, but nothing fast enough to be concerned about. After that I just sat on the couch very relaxed and watched tv for a while. I drifted off to sleep sometime after and woke up early the next morning feeling well rested and with a lot of energy. My lifted mood was very apparent the next day as well.

We’ll stick to weed

The FDA requires a black-box warning on Trazodon. They note that taking Trazodone hcl could increase the chance of becoming suicidal. Get this, the risk of suicide is greatest when starting treatment or when increasing or decreasing the dose of Trazodone. Suicide risk may be higher for people younger than 24 when using Trazodne. Keep in mind that this is a drug that’s supposed to treat depression not cause depression let alone suicide—especially in the people who are the most at-risk.

Why is weed better? Well these harmful side-effects don’t happen with marijuana—a wonderful, all natural antidepressant and sleep aid. Plus you can grow it in your backyard. You don’t have to buy it from a massive pharmaceutical company. If you live in a state like Colorado or Washington and are on the fence about using weed to treat depression or insomnia it’s perfectly legal there so what are you waiting for, man? If you live in a medical marijuana state you can use our alphabetical list to find marijuana in your area or a marijuana delivery service that can drop some off.

You might be interested in our other posts about pills. Take a look at our last on how to make . We’ve also written about two other famous painkillers that are inferior to the mighty herb AN627 and Watson 3202. Check ’em out when you get a chance. Have any questions or comments about why weed’s way better than Trazodone? Let us know in the comments section below…

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  • Franco Bartolozzi says:

    Marijuana is the best thing out their for people with SEVERE mental problems. I live in ny and nj, and i was diagnosed with Brain ischemia. That diagnosis comes with extra shit, PTSD and BPD. A lot of medical websites will SAY marijuana is bad for BORDERLINE PERSONALITY DISORDER. (YEAH SURE) try taking a seroquel (which in my states, they will give you a shit load of instead of marijuana) side effects are extremely dangerous. Remember its called MEDICAL PRACTICE. Not medical GARUNTEE. which basically means that doctors cannot rectify a mistake until SOMETHING HAPPENS. i have been using weed for 13 years STRAIGHT. fuck you PFIZER fuck all you pharmacudical FUCKS!!!! Take advil, take tylenol, take OXY!! Why sp i van die? Fuck all the PHARMA FUCKS SMOKE EAT DRINK WEEED!!!!